Reproductive health and metabolic profile features in adolescent girls born to mothers with preeclampsia

Introduction. Complicated pregnancy and delivery pose risks not only to maternal health but also to the offspring in later life. Preeclampsia (PE) has long-term effects on child development, increasing the risk of metabolic and endocrine disorders. However, studies investigating the impact of PE on the reproductive health in adolescent girls are limited, and existing data remain controversial, underscoring the relevance of the current study. Aim: to assess the reproductive health and metabolic profile in adolescent girls depending on maternal PE during pregnancy and childbirth. Materials and Methods. An ambispective cohort study was conducted. A total of 1,706 delivery records of women who gave birth to female infants in 2006, 2007 and 2008 were analyzed. From these, 184 adolescent girls who met the inclusion criteria were selected: singleton full-term spontaneous pregnancy, presence or absence of maternal PE, and live-born fullterm females delivered between 2006 and 2008. Participants were divided into two groups: main group – 128 girls born to mothers with moderate or severe PE, control group comprised 56 girls whose mothers had an uncomplicated pregnancy and delivery. A retrospective analysis of obstetric records and a prospective clinical assessment of adolescent girls were performed, including anthropometric evaluation with calculated standard deviation score (SDS) of body mass index (BMI), assessed menstrual and reproductive function, hormonal profiling, and ultrasound examination of the pelvic organs and mammary glands. Results. In the main group, a higher prevalence of dysmenorrhea (p = 0.027) and earlier age at menarche (p = 0.001) was observed compared to control group. At the same time, no significant inter-group differences in menstrual cycle regularity, menstrual blood loss, or time to cycle establishment (p > 0.05) were found. Evaluation of physical development revealed significant differences in BMI category distribution (p = 0.031). In main group, both underweight (20.3 % vs. 7.1 % in controls) and obesity (10.9 % vs. 7.1 %), including severe forms (class III and morbid obesity), were more frequently observed; the latter were absent in control group. Among girls in main group, fetal growth restriction (FGR) was observed significantly more frequently – 26.6 % vs. 0.0 % in controls, (p < 0.001), and both birth weight and birth length were significantly lower (p = 0.002 and p < 0.001, respectively). Incomplete menstrual cycle maturation (14.1 % vs. 10.7 %) and prolonged cycle establishment (> 3 years: 4.7 % vs. 0,0 %) tended to be higher in the main group although the difference was not statistically significant (p = 0.176). Conclusion. Maternal pregnancy complicated by preeclampsia is associated with altered reproductive health and metabolic profile in adolescent girls born to mothers with PE more frequently exhibiting primary dysmenorrhea, earlier menarche, and deviations in physical development such as bimodal distribution of BMI categories (increased prevalence of both underweight and obesity). These findings indicate a high-risk of menstrual dysfunction and metabolic disorders in girls born to mothers with PE, supporting a need for follow-up by a pediatric and adolescent gynecologist as well as development of personalized early prevention strategies.