Neurod2 knockdown in Xenopus laevis tadpole brain retains cells in a proliferating, progenitor-like state
Abstract
knockdown increased expression of cell cycle-associated genes and decreased nerve growth factor (NGF) and chromatin modifying genes. Our results suggest Neurod2 deficiency prevents neural progenitor cells exiting the cell cycle and differentiating, predisposing the brain to hyper-excitability.
Fields of Study & Subjects
Neurogenesis and neuroplasticity mechanisms
Developmental Biology and Gene Regulation
Neuroscience and Neuropharmacology Research
Publication details
- Journal / source
- PubMed
- Volume
- 2026
- Publication date
- 8 January 2026
- Language
- EN