Discussion on the Immunologic Mechanism of Zhuang Medicine External Treatment of Allergic Rhinitis Based on the Theory of Disease Caused by Toxin-Deficiency

Allergic rhinitis (AR) is an IgE-mediated Th2-type inflammatory disease of the nasal mucosa. It has a a high prevalence worldwide and significantly affects patients’ quality of life. Currently, Western medicine treatment can control symptoms, however, it still faces issues such as recurrence and long-term medication. Zhuang medicine, based on the theory of “disease caused by toxin-deficiency”, emphasizes the interaction and mutual influence of “toxin” and “deficiency” in causing the disease. This article holds that the occurrence and development of AR reflect the pathological dynamics and evolution of “toxin” and “deficiency”, which are reciprocally mutually causa. Based on the theory, Zhuang medicine external treatment, guided by the principles of “detoxifying and tonifying deficiency, unblocking pathways and regulating Qi”, demonstrate unique advantages in the clinical management of AR. This article aims to clarify the intrinsic connection between the “theory of disease caused by toxin-deficiency” and modern pathogenesis of AR, and systematically elucidate the mechanism and clinical application of the Zhuang medicine external treatment, hoping to provide innovative theoretical perspective and practical evidence based on the ethnic medical theory for the prevention and treatment of AR through integrated Chinese and Western medicine.