Cytotoxic lesion of corpus callosum associated with cerebral venous sinus thrombosis

Introduction - Cytotoxic lesion of corpus callosum (CLOCC) is a rare but increasingly recognized entity. It is associated with various etiologies including drug-related toxicity, epilepsy, infections, metabolic disturbances, and many other conditions. Here we present a rare case of CLOCC due to cerebral venous sinus thrombosis (CVST) in the postpartum period.Case report - A 25-year-old female was admitted due to persistent headaches on the third day of her postpartum period. The neurological examination did not reveal any focal neurological signs. She was diagnosed with CVST and splenium of corpus callosum (SCC) lesion with imaging features of FLAIR/ T2/DWI hyperintensity, ADC hypointensity, and lack of contrast enhancement. Extensive work-up did not unveil any other etiology. She was treated with low-molecular-weight heparin, warfarin, and acetazolamide. Six weeks later, brain imaging showed recanalization of the cerebral sinuses without any signs of permanent lesion in SCC. She was symptom-free at the two-year follow-up.Conclusion - It is crucial to recognize CLOCC and thus to unveil and treat its potential etiology. CVST should be considered in CLOCC cases, particularly in patients with prothrombotic states such as the postpartum period.