Chitosan-and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging

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General Information- **Data Set Title**: Chitosan-and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging- **Authors**: - Principal investigator and contact person: Dorota Chełminiak-Dudkiewicz, Nicolaus Copernicus University in Torun, e-mail: dorotachd@umk.pl.-Investigator: Miloslav Machacek, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic, e-mail:machamil@faf.cuni.cz-Investigator: Jolanta Dlugaszewska, Poznan University of Medical Sciences, e-mail: jdlugasz@wp.pl-Investigator: Magdalena Wujak, Nicolaus Copernicus University in Torun, e-mail: mwujak@cm.umk.pl-Investigator: Aleksander Smolarkiewicz-Wyczachowski, Nicolaus Copernicus University in Torun, e-mail: asmolarkiewicz@doktorant.umk.pl- **Date of data collection**: year 2025.- **Place of data collection**: Torun- **Keywords***: Dialdehyde Levan; Polysacharides; Wound dressing materialsData language**: English- **Sources of funding**: National Science Center (NCN) competition: SONATA 18- UMO-2022/47/D/NZ7/01821.2. Overview of data and files-**abbreviations**:DhLev - dialdehyde levanCBD@CS - cannabis oil-chitosan-based sponge1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a climate chamber4M-CBD@CS - cannabis oil-chitosan-based sponge after 4 months of storage in a climate chamber5M-CBD@CS - cannabis oil-chitosan-based sponge after 5 months of storage in a climate chamber6M-CBD@CS - cannabis oil-chitosan-based sponge after 6 months of storage in a climate chamberCBD@Lev - cannabis oil-levan-based sponge1M-CBD@Lev - cannabis oil-levan-based sponge after 1 month of storage in a climate chamber2M-CBD@Lev - cannabis oil-levan-based sponge after 2 months of storage in a climate chamber3M-CBD@Lev - cannabis oil-levan-based sponge after 3 months of storage in a climate chamber4M-CBD@Lev - cannabis oil-levan-based sponge after 4 months of storage in a climate chamber5M-CBD@Lev - cannabis oil-levan-based sponge after 5 months of storage in a climate chamber6M-CBD@Lev - cannabis oil-levan-based sponge after 6 months of storage in a climate chamber- **File List**:Fig.1.tiff: Characterization of the dialdehyde levan. ATR-FTIR spectra and SEM images. Legends: Lev-levan; DhLev - dialdehyde levanFig.2. tiff: The sponges' appearance after 0–6 months of storage in a climate chamber. a) Chitosan-based sponge and b) Levan-based sponge. Legend: CBD@CS - cannabis oil-chitosan-based sponge 1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber 2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber 3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a climate chamber 4M-CBD@CS - cannabis oil-chitosan-based sponge after 4 months of storage in a climate chamber 5M-CBD@CS - cannabis oil-chitosan-based sponge after 5 months of storage in a climate chamber 6M-CBD@CS - cannabis oil-chitosan-based sponge after 6 months of storage in a climate chamber CBD@Lev - cannabis oil-levan-based sponge 1M-CBD@Lev - cannabis oil-levan-based sponge after 1 month of storage in a climate chamber 2M-CBD@Lev - cannabis oil-levan-based sponge after 2 months of storage in a climate chamber 3M-CBD@Lev - cannabis oil-levan-based sponge after 3 months of storage in a climate chamber 4M-CBD@Lev - cannabis oil-levan-based sponge after 4 months of storage in a climate chamber 5M-CBD@Lev - cannabis oil-levan-based sponge after 5 months of storage in a climate chamber 6M-CBD@Lev - cannabis oil-levan-based sponge after 6 months of storage in a climate chamberFig.3.tiff: A SEM images of a) CBD@CS sponges and b) CBD@Lev sponges after storage in the climate chamber. B Porosity and C WVTR changes of the sponges after 0–6 months of storage. Legend: CBD@CS - cannabis oil-chitosan-based sponge 1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber 2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber 3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a climate chamber 4M-CBD@CS - cannabis oil-chitosan-based sponge after 4 months of storage in a climate chamber 5M-CBD@CS - cannabis oil-chitosan-based sponge after 5 months of storage in a climate chamber 6M-CBD@CS - cannabis oil-chitosan-based sponge after 6 months of storage in a climate chamber CBD@Lev - cannabis oil-levan-based sponge 1M-CBD@Lev - cannabis oil-levan-based sponge after 1 month of storage in a climate chamber 2M-CBD@Lev - cannabis oil-levan-based sponge after 2 months of storage in a climate chamber 3M-CBD@Lev - cannabis oil-levan-based sponge after 3 months of storage in a climate chamber 4M-CBD@Lev - cannabis oil-levan-based sponge after 4 months of storage in a climate chamber 5M-CBD@Lev - cannabis oil-levan-based sponge after 5 months of storage in a climate chamber 6M-CBD@Lev - cannabis oil-levan-based sponge after 6 months of storage in a climate chamberFig.4.tiff: Release of CBD from CBD@CS and CBD@Lev sponges after different storage periods in a climate chamber. Each value represents the mean of three independent replicates (n = 3). Legend: CBD@CS - cannabis oil-chitosan-based sponge 1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber 2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber 3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a climate chamber 4M-CBD@CS - cannabis oil-chitosan-based sponge after 4 months of storage in a climate chamber 5M-CBD@CS - cannabis oil-chitosan-based sponge after 5 months of storage in a climate chamber 6M-CBD@CS - cannabis oil-chitosan-based sponge after 6 months of storage in a climate chamber CBD@Lev - cannabis oil-levan-based sponge 1M-CBD@Lev - cannabis oil-levan-based sponge after 1 month of storage in a climate chamber 2M-CBD@Lev - cannabis oil-levan-based sponge after 2 months of storage in a climate chamber 3M-CBD@Lev - cannabis oil-levan-based sponge after 3 months of storage in a climate chamber 4M-CBD@Lev - cannabis oil-levan-based sponge after 4 months of storage in a climate chamber 5M-CBD@Lev - cannabis oil-levan-based sponge after 5 months of storage in a climate chamber 6M-CBD@Lev - cannabis oil-levan-based sponge after 6 months of storage in a climate chamberFig.5.tiff: Characterization of the activity of the tested sponges after 0–6 months of storage in a climate chamber. Ani-inflammatory (A) and antioxidant (B) properties of the sponges; (C) swelling rate. Legend: CBD@CS - cannabis oil-chitosan-based sponge 1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber 2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber 3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a climate chamber 4M-CBD@CS - cannabis oil-chitosan-based sponge after 4 months of storage in a climate chamber 5M-CBD@CS - cannabis oil-chitosan-based sponge after 5 months of storage in a climate chamber 6M-CBD@CS - cannabis oil-chitosan-based sponge after 6 months of storage in a climate chamber CBD@Lev - cannabis oil-levan-based sponge 1M-CBD@Lev - cannabis oil-levan-based sponge after 1 month of storage in a climate chamber 2M-CBD@Lev - cannabis oil-levan-based sponge after 2 months of storage in a climate chamber 3M-CBD@Lev - cannabis oil-levan-based sponge after 3 months of storage in a climate chamber 4M-CBD@Lev - cannabis oil-levan-based sponge after 4 months of storage in a climate chamber 5M-CBD@Lev - cannabis oil-levan-based sponge after 5 months of storage in a climate chamber 6M-CBD@Lev - cannabis oil-levan-based sponge after 6 months of storage in a climate chamberFig.6.tiff: The protein adsorption on the polysaccharide sponges. Amount of fibrinogen (A) and HSA (B) per sponge area. ⁎,#,$,&,^,! $ indicate p < 0.05 when compared to the corresponding CBD@CS, 1 M-CBD@CS, 2 M-CBD@CS, 3 M-CBD@CS, 4 M-CBD@CS, 5 M-CBD@CS, and 6 M-CBD@CS and CBD@Lev, 1 M-CBD@Lev, 2 M-CBD@Lev, 3 M-CBD@Lev, and 4 M-CBD@Lev, respectively. Legend: CBD@CS - cannabis oil-chitosan-based sponge 1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber 2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber 3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a climate chamber 4M-CBD@CS - cannabis oil-chitosan-based sponge after 4 months of storage in a climate chamber 5M-CBD@CS - cannabis oil-chitosan-based sponge after 5 months of storage in a climate chamber 6M-CBD@CS - cannabis oil-chitosan-based sponge after 6 months of storage in a climate chamber CBD@Lev - cannabis oil-levan-based sponge 1M-CBD@Lev - cannabis oil-levan-based sponge after 1 month of storage in a climate chamber 2M-CBD@Lev - cannabis oil-levan-based sponge after 2 months of storage in a climate chamber 3M-CBD@Lev - cannabis oil-levan-based sponge after 3 months of storage in a climate chamber 4M-CBD@Lev - cannabis oil-levan-based sponge after 4 months of storage in a climate chamber 5M-CBD@Lev - cannabis oil-levan-based sponge after 5 months of storage in a climate chamber 6M-CBD@Lev - cannabis oil-levan-based sponge after 6 months of storage in a climate chamberFig.7.tiff: Analysis of the biodegradation properties (A) and antibcterial properties (B) of the sponges. Legend: CBD@CS - cannabis oil-chitosan-based sponge 1M-CBD@CS - cannabis oil-chitosan-based sponge after 1 month storage in a climate chamber 2M-CBD@CS - cannabis oil-chitosan-based sponge after 2 months of storage in a climate chamber 3M-CBD@CS - cannabis oil-chitosan-based sponge after 3 months of storage in a c