Association of ovarian response with anogenital distance in patients undergoing ovarian stimulation for in vitro fertilization/intra cytoplasmic sperm injection: a prospective cohort study

Background: The study investigates whether Anogenital Distance (AGD), a permanent marker of the prenatal hormonal environment, is associated with established ovarian reserve markers (FSH, AMH, AFC). Crucially, the aim is to determine if AGD can predict Ovarian Sensitivity Index (OSI) and overall ovarian response during controlled ovarian stimulation (COS) for IVF/ICSI. Methods: This was a prospective cohort study conducted at an Indian IVF Reproductive and Biology Centre, located within the Department of Obstetrics and Gynaecology at Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi (n=40), aiming to evaluate the association of the anogenital distance (AGD), measured using digital calipers, with ovarian response, specifically the ovarian sensitivity index (OSI), and clinical outcomes in infertile women undergoing their first IVF/ICSI cycle. Results: The study confirmed that age and AFC are inverse determinants of ovarian response, with low responders being older, having lower AFC, and requiring the highest gonadotropin dose. This resulted in highly significant differences (p