INVESTIGATION OF THE POTENTIAL ROLE OF SERUM TRAIL AND TRAIL RECEPTORS IN BREAST CANCER

OBJECTIVE: Apoptosis is crucial for maintaining normal cellular homeostasis, but dysregulation may frequently be observed in breast cancer. This study aims to evaluate the serum levels of TRAIL, DR4, and DR5 in patients with breast cancer and the control group. Additionally, the serum levels of CCL2 and CCL5 will also be measured to provide a comprehensive analysis of inflammatory and apoptotic markers in breast cancer. MATERIAL AND METHODS: This case-control study consists of 62 breast cancer patients and 62 age-matched controls, enrolled in general surgery service at the Gazi University Medical Faculty Hospital. Serum parameters were measured prospectively via Enzyme-Linked Immunosorbent Assay. RESULTS: Serum levels of DR4 and DR5 were significantly higher in breast cancer patients compared to the controls (6.99±1.05 versus 4.61±0.61 ng/mL, p=0.003; 1.57±0.12 versus 1.03±0.10 ng/mL, p