Association of migraine with peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness: A cross-sectional OCT-based study

Purpose: Migraine is a frequent neurological condition that may cause ocular alterations as a result of disrupted neurovascular regulation. The impact extends to the thickness of the retinal nerve fiber layer along with that of the ganglion cell layer.This study aimed to assess the relationship between migraine and variations in peripapillary retinal nerve fiber layer (RNFL) as well as macular ganglion cell layer (GCL) thickness, using optical coherence tomography (OCT).Methods: A cross-sectional analytical design was employed, including 116 individuals with migraine and 116 age- and sex-matched healthy controls. All participants underwent a comprehensive ophthalmic examination along with spectral-domain OCT (Topcon 3D OCT-1 Maestro). The thickness of the peripapillary RNFL and the ganglion cell complex (GCC+ and GCC++) was compared between the two groups.Results: Mean pRNFL thickness was significantly lower in migraine patients (99.9 ± 8.2 μm) than controls (103.7 ± 7.6 μm; p