Optical coherence tomography angiography in uveitis: Insights into microvascular alterations and disease monitoring

Background: Uveitis encompasses a diverse range of inflammatory disorders affecting the uveal tract, posing diagnostic and management challenges that necessitate a comprehensive, multimodal imaging approach. Optical Coherence Tomography Angiography (OCTA) is a promising, noninvasive imaging modality gaining traction in the evaluation of ocular microvasculature changes associated with uveitic conditions.Aims: This study aims to characterize and compare OCTA imaging features across various forms of uveitis and assess the utility of OCTA in monitoring disease progression and therapeutic response.Materials and Methods: A prospective observational study conducted in the ophthalmology department of a tertiary care academic medical center.Patients diagnosed with different types of uveitis underwent OCTA as part of their diagnostic and follow-up imaging. OCTA images were analyzed for microvascular alterations such as non-perfusion areas, capillary network disruption, neovascularization, and choriocapillaris flow voids. These findings were correlated with clinical assessments and conventional imaging outcomes.Statistical Analysis Used: Descriptive statistics were employed to summarize OCTA features. Comparative analyses between uveitis subtypes were conducted using chi-square or Fisher’s exact test for categorical variables, and t-tests or Mann–Whitney U tests for continuous variables as appropriate. A p-value