Exploratory clinical observations of high-dose oral 70 k da hyaluronan fragments in subcutaneous fat reduction, inflammatory erythema, and facial vitality: A case series

Background: The naked mole-rat exhibits unusually high tissue concentrations of hyaluronic acid and minimal subcutaneous adipose tissue, which has stimulated interest in the potential biological roles of HA in tissue homeostasis. This exploratory case series aimed to document clinical observations following high-dose oral administration of 70 kDa HA fragments with respect to perceived changes in subcutaneous fullness, facial erythema, and facial vitality.Materials and Methods: Eleven Asian participants received oral 70 kDa HA fragments (5 g/day) for 40 consecutive days. Changes in perceived subcutaneous fullness, facial erythema, and facial vitality were evaluated using a modified 0–10 Visual Analog Scale (VAS). Safety and gastrointestinal tolerance were monitored throughout the intervention period.Results: After 40 days of administration, participants reported varying degrees of perceived reduction in facial and/or body subcutaneous fullness, along with improvements in facial erythema and vitality. Some participants noted visible changes as early as day 7. No adverse events were reported during the intervention period. Incidental improvements in gastrointestinal comfort and dry eye symptoms were also reported by a subset of participants.Conclusions: High-dose oral 70 kDa HA fragments were well tolerated in this exploratory case series and were associated with self-reported improvements in subcutaneous fullness appearance, facial erythema, and facial vitality. These preliminary observations warrant further investigation in larger controlled studies incorporating objective measurements.