When the Skin Speaks for the Bone Marrow: Sweet Syndrome and Pancytopenia as the Initial Manifestation of Occult AML
Abstract
This case report describes the presentation for a 65-year-old patient with Sweet's syndrome (SS) presenting with systemic symptoms of general weakness, fever, and painful skin lesions on the right arm. He reported a history of weight loss with night sweats, while skin lesions manifested as erythematous plaques and painful papules. The diagnosis was confirmed by skin biopsy, which showed features of significant neutrophilic infiltration on histopathology. Further investigations led to the diagnosis of AML associated with Sweet's syndrome. The study highlights the importance of prompt diagnosis of Sweet's syndrome as a paraneoplastic sign and of using multidisciplinary approach for diagnosis and management of patients with skin lesions and cytopenias.
Fields of Study & Subjects
Autoimmune and Inflammatory Disorders
Acute Myeloid Leukemia Research
Blood disorders and treatments
Publication details
- Journal / source
- International Journal of Hematology-Oncology and Stem Cell Research
- Volume
- 20
- Issue
- 1
- Pages
- 110–116
- Publication date
- 15 February 2026
- Language
- EN