Long-Term Sequelae of Chemotherapy in Pediatric Cancer Survivors: A Retrospective Study Of 50 Cases

Background: Advances in chemotherapy have markedly improved survival for childhood cancers, but long-term adverse effects can impair quality of life. This retrospective study describes late effects observed in 50 pediatric cancer survivors who completed chemotherapy and were followed at a single tertiary center. Methods: Medical records of 50 patients (age at diagnosis 0.8–16.5 years) treated with systemic chemotherapy between 2021–2024 and followed ≥2 years after end of therapy were reviewed. Data collected included demographics, diagnosis, chemotherapy agents and cumulative doses, radiation exposure, clinical and laboratory assessments during follow-up, and documented late effects (cardiac, endocrine, neurocognitive, auditory, renal, hematologic/secondary malignancy, fertility, growth, psychosocial). Outcomes were summarized with descriptive statistics and associations tested with χ² or Fisher’s exact test for categorical variables and t-tests or Mann–Whitney U for continuous variables. A p-value