The role of immunoregulatory blood proteins in the reproductive health of women living in the Northern and Arctic territories

A literature review is presented using the eLIBRARY.RU, Google Scholar and PubMed information databases for the period 2000–2025. The selection criterion was information on the role of immunoregulatory blood proteins in the reproductive health of women living on the Northern and Arctic territories. The article presents modern data on the role of transferrin, haptoglobin, immunoglobulins, and lipoproteins in physiological pregnancy, infertility, and spontaneous labor. In middle-aged women living on northern and arctic territories, increase of transferrin, haptoglobin, IgM concentrations affect the content of immunocompetent cells, cytokines, and the extracellular pool of receptors, while low levels of apoproteins B, A-I cause insufficient antioxidant and anti-inflammatory protection in the body. Decrease in antioxidant protection and deregulation of the immune response contribute to the increase in reproductive health risks in women living in northern and arctic regions, including menstrual and ovarian cycle disorders and pregnancy complications. The study of the role of blood proteins with immunoregulatory, anti-inflammatory, and antioxidant properties in assessing women’s reproductive health is a promising area.