Comparative Evaluation of Platelet Rich Plasma and Zinc Fluorophosphate Along with LCP for Healing of Long Bone Fractures in Dogs

Background: Objective of present study was to evaluate the efficacy of synthetic (zinc fluorophosphate) and biological (platelet rich plasma) bone substitutesalong with locking compression plate fixation for repair of long bone fractures in dogs. Methods: In this study, 36 clinical cases of fractures of different long bones were divided in three groups having 12 animals each.In group I animals, fracture was stabilized with Locking Compression Plate (LCP), while in groupsIIand III, platelet rich plasma (PRP) and zinc fluorophosphates, respectively were additionally used at the fracture site along with LCP. Result: Different clinical, radiographic and haemato-biochemical parameters were evaluated up to 3 months post-operatively, the progress of the fracture healing was assessed using a radiographic scoring system for bone formation and union. Highest values of bone formation, union and weight bearing score were observed in group III at all intervals as compared to other groups. Functional outcome, lameness grading and radiographic observations revealed that LCP with zinc fluorophosphate had superior outcomes, early bone formation, bone union, better weight bearing and improved gait, as compared to LCP alone or LCP with PRP. Results suggested that zinc fluorophosphate, along with LCP, is better than PRP and only LCP for osteosynthesis of long bones in dogs. In present study, Group III yielded best result followed by Group II and Group I.