From Framework to Action: Precision Medicine Policy Assessment Toolkit for Oncology

Background: Precision medicine (PM) is reshaping oncology through more accurate diagnosis, targeted therapies, and improved outcomes.However, the integration of PM into routine cancer care remains uneven globally, largely due to gaps in policy frameworks, infrastructure, financing, governance, and workforce capacity.These challenges risk widening existing health inequities, particularly in low-and middleincome countries.Methods: The Precision Medicine Policy Assessment Toolkit for Oncology (PM Toolkit) was developed through an evidence-based, multistakeholder process, including literature review, expert consultation, and analysis of real-world case studies.The Toolkit is structured around nine core domains of health system readiness and applies a tiered framework aligned with World Bank income-level classifications to ensure context sensitive and feasible policy guidance.Results: The PM Toolkit provides a country readiness framework, income-specific objectives, a self-assessment survey, and practical policy pathways to support stakeholders in prioritizing actions to integrate PM into public cancer pathways.Case studies from diverse settings demonstrate its applicability across health system contexts.Conclusion: This PM Toolkit offers a practical, adaptable, and equity-oriented approach to translating precision oncology from innovation to implementation.It supports policymakers and stakeholders in advancing sustainable, context-appropriate PM strategies worldwide.