[Analysis of association between HIF-1α gene polymorphism and different syndromes of early cough variant asthma patients and their lung function].

This study aims to explore the association between the polymorphism of HIF-1α gene and the susceptibility to early cough variant asthma(CVA) with Qi deficiency and blood stasis, lung and spleen Qi deficiency, liver fire invading lung, and wind invading lung defense, as well as the lung function. The study selected 120 CVA patients who visited the respiratory department from December 2021 to December 2023 as the research subjects and included them in the case group. According to the classification of TCM syndromes, patients in the case group were divided into Qi deficiency and blood stasis group(n=30), lung and spleen Qi deficiency group(n=26), liver fire invading lung group(n=26), and wind invading lung defense group(n=38). Another 60 healthy individuals who underwent physical examinations during the same period were selected as control group. The clinical data of the case group and the control group were compared. The polymorphism of the HIF-1α gene was analyzed. The distribution of the HIF-1α gene in the case group and the control group was compared. The association between the polymorphism of the HIF-1α gene and the risk of CVA occurrence was analyzed. The polymorphism of the HIF-1α gene in different clinical types of patients was analyzed. The association between the polymorphism of the HIF-1α gene and the clinical types and the association between the polymorphism of the HIF-1α gene and the lung function indicators of patients with Qi deficiency and blood stasis were analyzed. The results showed that compared with those in the control group, the HIF-1α level in the case group was significantly higher, and FVC, FEV_1, and FEV_1/FVC levels were significantly lower(P