Physicochemical evalution of mycophenolate mofetil’s dispersion: stability and administration in tubes

The aim of this study was to evaluate the stability of a liquid formulation of MMF 10 mg/mL at temperature of 20ºC-25ºC and 2ºC-8ºC. The vehicle was developed in the Pharmacotechnical Laboratory at the Federal University of Ceará, and the formulations were monitored for changes in pH, density, viscosity and sedimentation. The formulation showed good stability across all parameters at both temperatures, with a decrease in the active ingredient nearly to 90% after 15 days at 20ºC-25ºC, and after 47 days at 2ºC-8ºC. When administered via simulated nasoenteral tube, 95.75% of the drug was recovered as identified by High Performance Liquid Chromatography (HPLC). The formulation appears stable and represents a suitable option for patients who require enteral administration, simplifying the operations for nursing staff.