Clinical and Laboratory Characteristics and Mortality in Patients with Liver Cirrhosis

Background: To present clinical and laboratory characteristics and assess 28-day mortality in patients with liver cirrhosis (LC). Materials and Methods: The study included 137 patients (mean age 51±11; 75 (54,7 %) males) with LC. The diagnosis was established based on clinical, laboratory, and instrumental data. According to the CLIF-C OF organ dysfunction score, patients were divided into two groups: the main group (n=72, mean age 52±11; 37 (51,4 %) males) — with acute-on-chronic liver failure (ACLF), and the comparison group (n=65, mean age 49±11; 38 (58,5 %) males) — with decompensated liver cirrhosis (DC) without ACLF. Clinical parameters, inflammatory markers, ammonia and lactate levels, prognostic scores, and 28-day mortality were assessed. Statistical analysis was performed using IBM SPSS 26. Results: Among patients with LC, 72 (52,6 %) had DC and 65 (47,4 %) had ACLF. Alcoholrelated etiology was predominant (52,8 % and 63,1 %, respectively). Patients with ACLF were characterized by significantly more severe hepatic and renal dysfunction, systemic inflammation, and higher scores on all prognostic scales (p