Selenized neural stem cell exosomes for CNS trauma repair

Extracellular Vesicles and Circulating Nucleic Acids 2026 Open access

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Authors: Lina Zhu, Kailu Guo, Xi Liu, Yanlin Feng, Cuiping Zhang
DOI: 10.20517/evcna.2025.156
Cited by: 0
References: 5

Abstract

. introduces a hybrid exosome platform - selenized neural stem cell-derived exosomes (SeNExo) - that couples the biological functionality of neural stem cell exosomes with the antioxidant power of ultrasmall nanoselenium. SeNExo crosses the blood-brain barrier via apolipoprotein E (APOE)-lipoprotein receptor-associated protein-1 (LRP1) interaction, scavenges reactive oxygen species, and restores glial-neuron homeostasis. It demonstrates potent therapeutic efficacy in both traumatic brain injury and spinal cord injury mouse models. This work highlights a promising direction for engineering multifunctional, cell-free nanotherapeutics for central nervous system repair.

Fields of Study & Subjects

Extracellular vesicles in disease Selenium in Biological Systems Traumatic Brain Injury and Neurovascular Disturbances

Publication details

Journal / source
Extracellular Vesicles and Circulating Nucleic Acids
Volume
7
Issue
1
Pages
16–9
Publication date
9 January 2026
Language
EN