Precision Medicine Treatment of Alzheimer’s Disease: Successful Randomized Controlled Trial

Background: There is a critical need for effective therapeutics for Alzheimer’s. Personalized, precision medicine approaches represent a potentially effective strategy, and proof-of-concept trials have provided supportive data. Objective: To determine whether a precision medicine approach to Alzheimer’s at the mild cognitive impairment or early dementia stage is effective in a randomized controlled clinical trial. Methods: Seventy-three patients with mild cognitive impairment or early dementia were evaluated for biochemical, microbiological, genetic, epigenetic, and imaging parameters associated with cognitive decline, then assigned randomly to a precision medicine approach or standard of care treatment. Results: Statistically significant effects of the precision medicine approach were observed for overall neurocognitive functioning (d=1.12; 95% CI, 0.56-1.66; p