MRI-Documented Improvement of L4–5 Foraminal Disc Protrusion Following Non-Invasive Audio Neuromodulation: A Case Report

Lumbar foraminal disc protrusions with nerve root compression rarely resolve spontaneously in older adults and often require surgery. A 61-year-old woman with chronic L4–5 radiculopathy initiated Deep Brain Sound Stimulation (DBSS), a non-invasive neuromodulation protocol targeting the subventricular zone. One 21-minute audio session was delivered daily for 44 days. Pain decreased from 100% to 0% within six weeks, and analgesic use was discontinued. Treatment was stopped to monitor durability. Follow-up MRI five weeks later no longer described a left foraminal protrusion or left L4–5 root compression. DBSS may be associated with symptomatic and radiological improvement. Controlled trials are warranted.