Preventive Effect of Djulis on Dextran Sulfate Sodium-Induced Chronic Colitis in Mice

Background : Djulis is an aboriginal cereal crop native to Taiwan, and its effects on patients with inflammatory bowel disease (IBD) warrant exploration. The present study investigated whether consumption of djulis can alleviate chronic colitis induced by dextran sulfate sodium (DSS) in mice. Methods : Forty mice were randomly divided into five groups: blank group (B), control group (C), low-dose group (L), medium-dose group (M), and high-dose group (H). Body weight and disease activity index (DAI) were recorded throughout the study. Groups C, L, M, and H were administered with 2% DSS water on days 1–5 and 10–15 to induce chronic colitis. Groups L, M, and H were administered 5%, 10%, and 15% djulis, respectively. Serum and colon samples were collected for further analysis. Results : The DAI scores of groups L, M, and H were significantly lower than those of group C (P