Plant-Derived Amino-Acid vs. Bovine-Derived Protein Human Milk Fortifier in Preterm Infants < 34 Weeks’ Gestation: A Pilot Randomized Controlled Trial

Preprints.org 2026 Preprint Open access

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Authors: Nikhil Kumar M., Viraraghavan Vadakkencherry Ramaswamy, Nasreen Banu Shaik, Laxman Basany, Abid Ali Hasan Ali, V. Sree Ramya
DOI: 10.20944/preprints202602.0852.v1
Cited by: 0

Abstract

Background: Bovine milk protein-based human milk fortifiers (HMFs) are routinely used in preterm infants in low- and middle-income countries (LMICs) but are associated with potential adverse effects. Plant-derived amino-acid based HMFs are a promising alternative, but comparative data from randomized controlled trials (RCTs) are lacking. This pilot RCT aimed to evaluate the feasibility, safety, and growth outcomes of a novel plant-derived amino-acid based HMF compared to a bovine-derived whole protein based HMF in preterm infants

Fields of Study & Subjects

Infant Nutrition and Health Infant Development and Preterm Care Breastfeeding Practices and Influences

Publication details

Journal / source
Preprints.org
Publication date
11 February 2026
Language
EN
Document type
Preprint