A Seven-Year Study of Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections in a Tertiary Hospital in Greece: A Shift Toward Metallo-β-Lactamase and Dual-Carbapenemase Strains

Preprints.org 2026 Preprint Open access

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Authors: Eleni E. Mylona, Sofia Kostourou, Dimitroula Giankoula, Chrysoula Kolokotroni, Paraskevas Tsilikis, Nikolaos Koudoumnakis, Maria Papagianni, Dimitris C. Kounatidis, Natalia G. Vallianou, Efstathia Perivolioti, Vasileios Papastamopoulos
DOI: 10.20944/preprints202604.0076.v1
Cited by: 3

Abstract

Background: Carbapenem-resistant Klebsiella pneumoniae (CRKp) remains a critical driver of antimicrobial resistance (AMR) in hospital settings worldwide. Methods: This study examined trends in CRKp bloodstream infections over a seven-year period (2019–2025) in a tertiary care hospital in Greece, with particular attention to resistance patterns and patient outcomes, including the impact of the COVID-19 pandemic. Results: A total of 671 non-duplicate CRKp isolates were analyzed and classified into three groups: KPC producers (67.4%), dual carbapenemase producers (17.4%), and single metallo-β-lactamase (MBL) producers (15.2%). Overall incidence showed a slight but non-significant increase over time. KPC-producing strains rose significantly until 2022 (p

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Nosocomial Infections in ICU Antibiotic Use and Resistance

Publication details

Journal / source
Preprints.org
Publisher
MDPI AG
Publication date
1 April 2026
Document type
Preprint