Safety and effectiveness of a portable nasal high-flow device for improving exercise tolerance in patients with chronic obstructive pulmonary disease: a study protocol for an open-label, randomized, crossover pilot trial

Journal of Thoracic Disease 2026 Open access

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Authors: Chizu Fukushima, Susumu Fukahori, Jun Iriki, Yusei Tsukamoto, Yasushi Obase, Ryo Kozu, Yorihide Yanagita, Takao Ayuse, Naoki Hosogaya, Masatoshi Hanada, Masato Oikawa, Yurika Kawazoe
+5 more Shinnosuke Takemoto, Takahiro Takazono, Noriho Sakamoto, Tomoya Nishino, Hiroshi Mukae
DOI: 10.21037/jtd-2025-aw-2316
Cited by: 0

Abstract

Background: during exertion may improve exercise tolerance in patients with COPD; however, its safety and effectiveness in ambulatory patients have not yet been established. Methods: -tests and mixed-effects models that are appropriate for a crossover design. Discussion: rather than long-term training effects of repeated use. Trial Registration: The study is registered in the Japan Registry of Clinical Trials (jRCT; trial ID jRCTs072240116; registered on February 20, 2025; https://jrct.mhlw.go.jp/latest-detail/jRCTs072240116). This article describes the protocol version 1.1 (March 11, 2025).

Fields of Study & Subjects

Chronic Obstructive Pulmonary Disease (COPD) Research Respiratory Support and Mechanisms Cardiovascular and exercise physiology

Publication details

Journal / source
Journal of Thoracic Disease
Volume
18
Issue
2
Pages
175–175
Publication date
1 February 2026
Language
EN