Trans-stenotic pressure gradient in symptomatic transverse sinus stenosis: clinical, laboratory, and imaging correlates

Background: The trans-stenotic pressure gradient (TPG) is a critical pathophysiological factor in symptomatic transverse sinus stenosis (TSS) and serves as a principal hemodynamic indicator for determining the necessity of stent placement. However, the gold standard of TPG measurement requires venous manometry guided by digital subtraction angiography, which is an invasive procedure associated with significant technical complexity, substantial cost, and procedural risks. In recent years, there has been growing interest in noninvasive image-based TPG estimation methodologies. However, a comprehensive multivariate analysis incorporating clinical parameters, laboratory biomarkers, and imaging indicators remains conspicuously absent in recent research. The purpose of this study was to investigate the clinical, laboratory, and imaging parameters that exhibit correlations with the TPG in TSS. Methods: -tests for continuous data and chi-squared tests for categorical data. We analyzed the correlation of the TPG with clinical characteristics (pulsatile tinnitus side, gender, age, and body mass index), laboratory results (blood glucose, blood lipid, routine blood examination, laboratory thyroid function test, coagulation test, and serum sex hormone levels), and CTV signs (the degree, length, and type of TSS; outflow laterality of the transverse sinus; and confluence point of the Labbé vein). Independent variables were determined, and a multivariate linear regression model was applied to assess their influences on TPG. Results: (R=0.67; P