Application of low-dose “one-stop” myocardial computed tomography perfusion imaging in coronary artery disease

Background: Coronary computed tomography angiography (CCTA) has provided excellent anatomical detail for coronary artery disease (CAD), but does not provide hemodynamic assessment. The application of conventional computed tomography perfusion (CTP) combined with CCTA to address this issue has been found to increase the scan time, radiation dose, and contrast media (CM). This study aimed to evaluate the feasibility of the low-dose "one-stop" myocardial CTP as an innovative computed tomography (CT) examination that could comprehensively assess patients suspected of CAD in a single scan. Methods: Consecutive patients (n=94) with suspected CAD who underwent the 70 kV "one-stop" CTP and gender- and age-matched patients (n=62) who underwent conventional CCTA were included. The best enhanced CTP phase for coronary arteries was selected as the CCTA phase. The CM and effective dose (ED) were recorded. The image quality of the two groups was assessed. Patients who underwent CTP were divided into three groups [normal (0%, n=14), non-significant (1-49%, n=31), and significant stenosis (50-100%, n=49)] on the basis of degree of coronary stenosis. The cardiac function, myocardial strain, and myocardial blood flow (MBF) of each subgroup were analyzed. Results: . 125.53±4.55 mL/100 mL/min, P