Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in relation to erectile dysfunction: a cross-sectional study

Background: Studies have shown that many diseases can be correctly predicted by the ratio of non-high-density lipoprotein cholesterol (NHDL-C) to serum high-density lipoprotein cholesterol (HDL-C) (NHHR). However, the association between NHHR and erectile dysfunction (ED) risk is unknown. This study looked into the probable link between NHHR and ED occurrence. Methods: This study made use of data from the National Health and Nutrition Examination Survey (NHANES), which was carried out between 2001 and 2004. The NHDL-C level was divided by the HDL-C level to calculate the NHHR. To look at the connection between ED and NHHR, the researchers employed a range of statistical techniques, such as subgroup analysis, multivariate logistic regression modeling, and smoothed curve fitting. Results: In the end, 3,961 individuals were enrolled for the study, 2,800 of whom did not have ED, and 1,161 of whom did. NHHR had a strong negative association with ED occurrence. For every unit increase in NHHR, the prevalence of ED fell by 9% in the fully adjusted model. Participants in the highest quartile (Q4) of the NHHR experienced a significantly lower incidence of ED than those in the lowest quartile (Q1). Curve fitting revealed a negative association between NHHR and ED; however, interaction tests and subgroup analysis demonstrated that the substantial relationships between the various subgroups of variables were independent. Conclusions: Evidence points to a direct correlation between a lower incidence of ED and greater NHHR levels.