Identification and validation of a novel estrogen-related model for breast cancer to predict the prognosis
Abstract
Background: Breast cancer (BRCA) is a common malignant tumor in women globally and has a poor prognosis. Molecular targeted therapy is a promising way for improving the treatment of BRCA. This study aimed to identify potential biomarkers for BRCA and construct a prognostic model. Methods: validation was finally performed. Results: overexpression significantly enhanced the invasion and migration of BRCA cells. It also inhibited the expression levels of p-STAT5, p-STAT3 and p-smad2/3 in BRCA cells. Conclusions: We identified four hub genes closely related to the prognosis of BRCA, and a risk model constructed by these four genes may be useful for risk stratification and prognosis evaluation in BRCA patients.
Fields of Study & Subjects
Breast Cancer Treatment Studies
Estrogen and related hormone effects
HER2/EGFR in Cancer Research
Publication details
- Journal / source
- Translational Cancer Research
- Publisher
- AME Publishing Company
- Volume
- 15
- Issue
- 2
- Pages
- 107–107
- Publication date
- 1 February 2026
- Language
- EN