Adjunctive use of Saccharomyces boulardii versus bismuth subsalicylate in the management of non-Clostridioides difficile nosocomial diarrhea in severely ill patients: a three-arm randomized controlled trial
Abstract
Background: ) versus BSS as an adjunctive treatment for nosocomial diarrhea. Methods: (Sb group) or BSS (BSS group), compared to standard care (SC group). Treatment outcomes including stool weight, frequency and consistency were compared between groups. Results: SC 0.2, P=0.95). No adverse event was reported. Conclusions: and BSS added no benefit in treatment of non-CDI nosocomial diarrhea. These were applicable across all outcomes including weight, frequency and consistency of stool. More studies are needed to ascertain a better treatment for nosocomial diarrhea. Trial Registration: Thai Clinical Trials Registry Identifier TCTR20250904004.
Fields of Study & Subjects
Clostridium difficile and Clostridium perfringens research
Probiotics and Fermented Foods
Gastrointestinal motility and disorders
Publication details
- Journal / source
- Translational Gastroenterology and Hepatology
- Volume
- 11
- Pages
- 17–17
- Publication date
- 1 January 2026
- Language
- EN