Seroprevalence of HIV, HBV, HCV, and Syphilis Among Blood Donors in Omdurman, Sudan (2019–2022): A Retrospective Study

Background: Transfusion-transmitted infection (TTI) poses significant risks to blood transfusion safety and represents a major public health challenge in Sudan.However, current data on TTI prevalence among blood donors is limited.This study aimed to assess the prevalence of TTI among male blood donors at the Blood Bank of Nao Teaching Hospital, Omdurman, Sudan, from January 2019 to December 2022.Methods and Results: A retrospective 4-year descriptive cross-sectional study was conducted using blood donation records to examine the prevalence of TTI, including human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV), and syphilis.Data were analyzed for trends over the four-year period.The study identified a total TTI prevalence of 8.8% (302 of 3401 donors).Among TTI, HBV had the highest prevalence at 4.29%, followed by syphilis at 3.91%.HIV prevalence was 0.56%, and HCV prevalence was 0.12%.No cases of co-infection were reported.The overall TTI prevalence declined from 10.2% in 2019 to 6.9% in 2022.Conclusion: The findings emphasize the importance of ongoing monitoring and improved screening measures to enhance blood safety in Sudan.The high prevalence of HBV and syphilis underscores the need for targeted public health campaigns to raise awareness and promote safe blood donation practices.(InternationalJournal of Biomedicine.