Interplay of Serum IL-6 and Vitamin D in Overweight, Non-Anemic Women of Reproductive Age with Systemic Lupus Erythematosus

Background: Systemic lupus erythematosus (SLE) is a chronic, potentially life-threatening autoimmune disorder that damages various tissues and organs.It is more prevalent in women than in men.Real-world medical practice provides comprehensive clinical and laboratory information.A variety of factors complicate processes in patients with SLE.Two important risk factors, serum interleukin-6 (IL-6) and vitamin D, are to be investigated to determine their precise role in SLE. Methods and Results:We analyzed variation in serum IL-6 and vitamin D, their association, and other characteristics in normalweight SLE (NW-SLE) and overweight SLE (OW-SLE), compared with NW controls (NW-C) and OW controls (OW-C).The enzyme-linked immunosorbent assay (ELISA) kit methods were used for diagnostic purposes and to determine vitamin D and IL-6 levels.Conventional methods were used to record the other variables, including hemoglobin (Hb), hepcidin (Hp), body mass index (BMI), menstrual cycle length (MCL), and menstrual phase duration (MPD).Serum levels of IL-6 presented significant variations for NW-SLE compared to NW-C (P