Hydrogen sulfide binds to the catalytic zinc ion in HDAC6 to modulate enzyme activity via an alternative deacetylation pathway

Research Square 2026 Preprint Open access

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Authors: Yi‐Chun Zhu, Chen Sun, Yin-fang Wang, Shengyang Cai, Kui-Fang Xie, Xue-Pan Mu, Zhini Zhu, Yulin Chao, Zixuan Zhou, Xiqing Bian, Wen Miu, Jian‐Lin Wu
+12 more Jingwei Weng, Jiaqi Zhu, Ying Chen, Wenlong Xue, Meng-yao Li, Ai-Qiu Chi, Qian Ding, Ming-Jie Wang, Bei‐Bei Tao, Igor Ying Zhang, Yi-Zhun Zhu, Qianhui Qu
DOI: 10.21203/rs.3.rs-777997/v1
Cited by: 0

Fields of Study & Subjects

Histone Deacetylase Inhibitors Research Sulfur Compounds in Biology Enzyme function and inhibition

Publication details

Journal / source
Research Square
Publication date
12 January 2026
Document type
Preprint