Loss of lysyl hydroxylase 2 activates CRP-mediated cancer invasion through MEK/ERK/MMP9 signaling in the bone-microenvironment

Research Square 2026 Preprint Open access

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Authors: Saori Tomiku, Atsushi Kasamatsu, Tomoaki Saito, Reo Fukushima, Yuki Nishimura, Tamon Narukawa, Anna Tomimatsu, Masumi Igari, Yui Shirafuji, Manabu Iyoda, Dai Nakashima, Mitsuo Yamauchi
+2 more Joel Moss, Katsuhiro Uzawa
DOI: 10.21203/rs.3.rs-7989174/v1
Cited by: 0
References: 28

Fields of Study & Subjects

Protease and Inhibitor Mechanisms Bone and Dental Protein Studies Bone Tumor Diagnosis and Treatments

Publication details

Journal / source
Research Square
Publication date
12 January 2026
Document type
Preprint