Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST

Research Square 2026 Preprint Open access

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Authors: Tom Schulz, Maria Beerbaum, Andrea Scrima, Hannah Jantzen, Alina Teuber, Thomas Mühlenberg, Lisa Ebel, Fernanda Garcia-Fóssa, Jörn Weisner, Matthias Philipp Müller, Sonja Sievers, Sebastian Bauer
+1 more Daniel Rauh
DOI: 10.21203/rs.3.rs-8307571/v1
Cited by: 0

Fields of Study & Subjects

Gastrointestinal Tumor Research and Treatment Protein Degradation and Inhibitors Fibroblast Growth Factor Research

Publication details

Journal / source
Research Square
Publication date
7 January 2026
Document type
Preprint