Iron-Catalyzed Stereospecific Heterocycle N-Glycosylation with Glycal Epoxides

Research Square 2026 Preprint Open access

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Authors: Xiao-Wen Zhang, Dakang Zhang, Zixiang Jiang, Hao Xu
DOI: 10.21203/rs.3.rs-8650471/v1
Cited by: 1

Abstract

Abstract Stereospecific N -glycosylation of heterocycles with glycal epoxides could readily provide valuable building blocks for drug discovery, but heterocycle N -glycosylation with a pyranose-based glycal epoxide is still difficult using existing methods. We report herein an iron-catalyzed, stereospecific heterocycle N -glycosylation method for these glycal epoxides in high yields and with low catalyst loadings. This method is functional-group tolerant and effective for a wide variety of functionalized, complex glycal epoxides and heterocycles.

Fields of Study & Subjects

Carbohydrate Chemistry and Synthesis Carbon dioxide utilization in catalysis Chemical Synthesis and Analysis

Publication details

Journal / source
Research Square
Publisher
Springer Science and Business Media LLC
Publication date
21 January 2026
Language
EN
Document type
Preprint