Lipoprotein-associated phospholipase A2 and Its Association with Acute Coronary Syndrome: A Comprehensive Analysis of the Correlation Between Coronary Artery Disease Severity and Post-percutaneous coronary intervention Cardiovascular Endpoint Events

Abstract Background: As an emerging inflammatory marker involved in atherosclerosis, Lp-PLA2 plays an important role in the occurrence and development of ACS. Objective: This study aims to investigate the correlation between Lp-PLA2 levels and both the severity of coronary artery lesions in ACS patients and the incidence of cardiovascular endpoint events following PCI. Patients and methods:Patients initially diagnosed with ACS who underwent CAG and PCI at the First People's Hospital of Chenzhou City between January 2019 and July 2022 were enrolled in the study and subsequently followed up for a 36-month period. Result : 1.In the classification of coronary artery lesion severity based on the Gensini score, after adjusting for confounding factors through binary logistic regression analysis, it was demonstrated that elevated serum Lp-PLA2 concentration constitutes an independent risk factor for the severity of coronary artery lesions in patients with ACS,(OR=2.114).2.In the stratification analysis based on cardiovascular endpoint events, after adjusting for confounding factors through Cox proportional hazards regression analysis, elevated Lp-PLA2 levels were identified as an independent risk factor for cardiovascular endpoint events in ACS patients following PCI (RR=2.08).3.In the stratification based on Lp-PLA2 concentration levels, subsequent to multivariate adjustment through binary logistic regression analysis, it was demonstrated that both smoking status and LDL-C levels exhibited significant positive associations with Lp-PLA2 concentration, respectively. Conclusion: Lp-PLA2 concentration serves as an independent prognostic indicator for both the severity of coronary artery lesions in ACS patients and the incidence of cardiovascular endpoint events following PCI.