A Study on Clinical Efficacy and Differences between the Endoscopic Fusion and the Oblique Lateral Interbody Fusion in the Treatment of Single-Segment Meyerding garde I and II spondylolisthesis

Abstract Objective： This study aims to compare the clinical outcomes and differences between the endoscopic fusion and the oblique lateral interbody fusion in the management of Meyerding grade I and II lumbar spondylolisthesis. Methods: . A prospective observational study was conducted, enrolling 86 patients with lumbar spondylolisthesis who were admitted to our institution between January 2021 and June 2024. Based on patients’ autonomous selection of surgical strategies, the cohort was stratified into the endoscopic fusion group (n = 45) and the oblique lumbar interbody fusion (OLIF) group (n = 41). All patients completed a postoperative follow-up period of no less than 12 months.The following outcomes were compared between the two groups: operative time, intraoperative blood loss, postoperative drainage volume, postoperative bed rest duration, postoperative hospital stay, spondylolisthesis reduction distance, increase Intervertebral space height, postoperative complication incidence, postoperative Visual Analogue Scale (VAS) score, and Oswestry Disability Index (ODI) score. Lumbar fusion status was assessed for all patients in both groups at each follow-up visit, in accordance with the Bridwell classification system. According to the modified MacNab classification, the excellent and good rates of the two groups of patients at the last follow-up were evaluated and compared. Results: Patients in the OLIF group exhibited superior perioperative outcomes in terms of operative time (167.09±50.59min vs 112.31±26.95min), intraoperative blood loss (167.73±42.27mL vs 114.19±24.54mL), postoperative drainage volume (154.67±22.13mL vs 98.69±10.91mL), and increase in intervertebral space height(4.46±1.79mm vs 5.17±1.65mm）compared with the endoscopic fusion group, with all differences reaching statistical significance (P0.05). Nevertheless, regarding the restoration of intervertebral space height, the OLIF procedure exhibited superior performance (5.17±1.65mm vs 4.4±1.79mm, P