Onset Age May Not Increase Kidney Disease Burden among Adult-Onset Type 1 DiabetesPatients—A Multi-Center Cross-Sectional Study

Abstract Background The incidence of adult-onset type 1 diabetes (T1DM) is rising globally, yet the association between onset age and kidney disease burden—encompassing diabetic kidney disease (DKD), abnormal kidney function, microalbuminuria, and high progression risk of DKD—remains unclear in this population. This multi-center cross-sectional study aimed to investigate this correlation, addressing a critical knowledge gap for clinical practice and public health management. Methods A total of 481 adult-onset T1DM participants from the Guangdong T1DM Translational Medicine Study were stratified by onset age into