Late response to nalfurafine hydrochloride for pruritus in patients with chronic liver disease: a retrospective data analysis
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Abstract Background: Nalfurafine hydrochloride is used for refractory pruritus; however, real-world data on its efficacy with long-term administration, particularly in late responders who initially failed treatment, are limited. We aimed to evaluate the efficacy of nalfurafine hydrochloride in patients with chronic liver disease and clarify the incidence and characteristics of late responders. Methods: A retrospective analysis of data of 210 patients who received nalfurafine hydrochloride for chronic liver disease-associated pruritus at our hospital since June 2015 was conducted. Efficacy at 12 weeks was evaluated in 76 patients for whom visual analog scale (VAS) assessment was possible. Results: Among all 76 patients, the VAS score significantly decreased from 55.2 before treatment to 30.0 after 12 weeks (P
Fields of Study & Subjects
Dermatology and Skin Diseases
Liver Diseases and Immunity
Liver Disease and Transplantation
Publication details
- Journal / source
- Research Square
- Publication date
- 16 March 2026
- Language
- EN
- Document type
- Preprint