Clinical Study of Atopic Dermatitis Treated using the saehim system: A Six-Stage Self-Healing Approach for Atopic Dermatitis and Inflammatory Skin Diseases

Abstract Background: Atopic dermatitis is a chronic inflammatory skin disorder characterized by recurrent flares and heterogeneous clinical courses. Conventional management primarily focuses on immunosuppressive or symptom-oriented interventions, which may provide short-term control but are often associated with relapse after treatment discontinuation. Alternative therapeutic frameworks that emphasize long-term recovery processes remain insufficiently explored. Objective: This study aimed to evaluate the clinical outcomes and recovery patterns observed during treatment with the saehim system, a structured six-stage, non-suppressive therapeutic framework applied in routine clinical practice, and to describe its sequential recovery characteristics in patients with atopic dermatitis. Methods: A prospective observational case-series study was conducted involving 35 patients with atopic dermatitis, with follow-up periods ranging from 6 to 34 months. All patients received oral monotherapy with saehim (SRM1), without the use of topical agents, corticosteroids, immunosuppressants, biologics, or adjunctive dermatologic treatments. Clinical outcomes were assessed using longitudinal time-series clinical photographs, the Scoring Atopic Dermatitis (SCORAD) index, and patient-reported symptom assessments. Results: Across the study cohort, a reproducible staged recovery pattern was observed, progressing from stabilization of acute inflammation to keratin formation and desquamation, followed by restoration of normal skin architecture. These sequential recovery patterns were consistently observed across different age groups, anatomical regions, and baseline disease severities. Sustained clinical remission was maintained during the follow-up period, including among pediatric patients with presumed genetic susceptibility. Conclusion: In this observational case series, treatment with the saehim system was associated with reproducible, staged recovery patterns and sustained clinical stabilization without reliance on immunosuppressive therapy. These findings suggest that a physiology-oriented, non-suppressive therapeutic framework may offer a clinically relevant complementary approach for the long-term management of atopic dermatitis, warranting further controlled investigations. Clinical Study of Atopic Dermatitis Using the saehim system