Real-time neutron monitoring for boron neutron capture therapy using 10B-integrated hybrid perovskite thin-film sensors

Abstract Hybrid organic–inorganic perovskites (HOIPs) are leading candidates for next-generation optoelectronics, driving rapid advancements in efficiency and applications, such as neutron detectors, due to their exceptional optoelectronic properties, including high-charge mobility and high-flux capability. High-flux neutron detector architectures have been investigated for real-time dosimetry; however, robust devices suitable for boron neutron capture therapy (BNCT) remain limited. In this study, we present the use of HOIP thin-film sensors integrated with developed 10B conversion layer for neutron detection in BNCT monitoring. A self-biased ITO/SnO2/FAPbI3/Spiro-OMeTAD device was laser-patterned to a 5 × 5 mm2 active area and coupled with an electrosprayed 10B film having an equivalent thickness of 3.3 μm, which was optimized based on cold-neutron transmission measurements. Air gap elimination between the converter and Au electrode markedly increased neutron sensitivity. In the KUR-HWNIF BNCT field, converted devices yielded nA-level currents that were linear with neutron flux up to ~109 s−1 cm−2. The γ-noise fraction of ~0.012% facilitated 1-s real-time readout and stable signal performance at neutron fluences up to 1013 cm−2. The stability, combined with negligible post-irradiation current–voltage changes, establishes converted HOIP thin-film sensors as flexible, self-diagnosable real-time BNCT neutron monitors suitable for clinical use.