Histopathological Evaluation of Anti-Atherosclerosis Activity of Terminalia Catappa in vivo

Abstract The current study determined the anti-atherosclerotic activity of Terminalia catappa using a diet-induced murine model in vivo. Our in vivo murine model using atherogenic diet induced atherosclerosis. Histological examinations of the diet-induced atherosclerosis indicated an atherogenic-related phenotype. Treatment with Terminalia catappa decreased cholesterol deposits in the lumen of the blood vessels in the aorta, heart, and liver. Protein interactome and metabolomic network in this study imply potential mechanisms and biomarkers of atherosclerosis. Protein interactome demonstrated that actin is the central switch of atherosclerosis through plaque rupture, thrombosis, macrophage, and cystic fibrosis as potential pathogenic mechanisms. Metabolome mapping reveals that cholesterol metabolism is directly connected to the aromatic amino acid pathway, fatty acids, lysophosphatidylcholine, citric acid, creatine, and cholic acid metabolism. The current study suggests the comprehensive functional profiles of atherosclerosis mechanisms. Our results propose that Terminalia catappa has the potential to cease the progression of atherosclerosis.