Comparative Glycaemic and Insulinaemic Response to Table Sugar versus Monk Fruit: An N-of-1 Pilot Self-Experiment

Background: Excessive intake of refined sugar is associated with post-prandial hyperglycaemia and hyperinsulinaemia, contributing to insulin resistance and cardiometabolic disease (1,2). Monk fruit (Siraitia grosvenorii) is increasingly used as a non-nutritive sweetener, yet limited human data exist regarding its acute glycaemic and insulinaemic effects (3, 5). Objective: To compare post-prandial blood glucose and insulin responses following ingestion of table sugar versus monk fruit in a controlled self-experiment. Methods: A prospective crossover N-of-1 study was conducted comparing metabolic responses after ingestion of 75 g table sugar and 75 g monk fruit sweetener on separate days. Results: Table sugar caused a marked rise in blood glucose and insulin, whereas monk fruit showed minimal deviation from fasting values. Conclusion: Monk fruit demonstrated a negligible glycaemic and insulinaemic response compared to table sugar.