A Correlative Study of Cardiac Enzymes and Diastolic Dysfunction in Patients with Acute Coronary Syndrome

Background: Acute Coronary Syndrome (ACS) is a leading cause of global morbidity and mortality. While systolic function is routinely assessed, the role of diastolic dysfunction (DD) and its correlation with the extent of myocardial injury, as indicated by cardiac enzymes, is increasingly recognized. This study aimed to evaluate the prevalence of DD in ACS patients and examine its relationship with Creatine Kinase-MB (CK-MB) levels. Methods: A cross-sectional study was conducted on 150 patients admitted with ACS. Diastolic function was assessed via 2D Echocardiography and classified as normal, impaired LV relaxation (Grade 1), or pseudonormal/restrictive (Grade 2/3/4). CK-MB levels were measured upon admission. Statistical analysis was performed using SPSS. Results: The mean age was 49.87 years with a near-equal gender distribution. A highly significant positive correlation was found between CK-MB levels and the severity of DD (Spearman's rho = 0.854, p