Diagnostic Correlation of Imaging and Histopathology in Giant Breast Masses: A Prospective Observational Study

Giant breast masses, defined as lesions over 5 cm, present diagnostic challenges due to their size and varied pathology. This prospective study evaluated 50 women with palpable giant breast lumps using mammography, ultrasonography, and image-guided biopsy. Imaging findings were compared with histopathology to assess diagnostic agreement. Infiltrative carcinoma was the most common malignancy, while benign phyllodes tumours were the largest benign group. A strong correlation was observed between higher BI-RADS categories and malignancy. These findings highlight the usefulness of a combined clinical, imaging, and biopsy approach for accurate diagnosis and informed treatment of large breast masses.