Solitary Testicular Metastasis from Prostate Cancer

Aim: To report a rare case of solitary testicular metastasis from prostatic adenocarcinoma and emphasize its clinical and pathological significance. Objectives: To describe the clinical presentation, histopathological findings, and possible mechanisms of testicular metastasis in a patient with prostate cancer. Discussion: Testicular metastasis from prostate cancer is extremely rare and usually indicates advanced disease. A 53-year-old male presented with urinary symptoms and unilateral testicular enlargement. Investigations revealed elevated serum PSA levels and prostatic adenocarcinoma with a Gleason score of 7 (3+4). Histopathological examination of the orchiectomy specimen showed gland-forming tumor deposits within the testicular parenchyma, consistent with metastatic adenocarcinoma. The proposed mechanisms of spread include retrograde venous or lymphatic dissemination, arterial embolism, and endocanalicular extension. Due to its rarity, testicular metastasis may be overlooked clinically, underscoring the importance of thorough evaluation.