Mycosis Fungoides in Skin Nodule

Aim: To highlight the cytological features of mycosis fungoides and evaluate the diagnostic utility of fine-needle aspiration cytology (FNAC) in suspected cases. Objectives: To describe the FNAC findings in two clinically suspected cases of mycosis fungoides and emphasize the importance of cytology supported by immunohistochemistry in early diagnosis. Discussion: Mycosis fungoides is the most common primary cutaneous T-cell lymphoma but remains diagnostically challenging on cytology due to its rarity and morphological variability. FNAC smears in both cases showed atypical medium-to-large lymphoid cells with dense chromatin, irregular nuclear contours, and prominent nucleoli. Immunohistochemistry revealed positivity for CD3 and CD45, confirming T-cell lineage. Awareness of these cytomorphological features, along with clinical correlation, is crucial to avoid misdiagnosis. Early recognition on FNAC can facilitate timely management and improve patient outcomes.