Study of Role of Magnetic Resonance Spectroscopy in Evaluation of Intracranial Space Occupying Lesions

Background: Intracranial space occupying lesions (ICSOLs) include a wide spectrum of neoplastic and non-neoplastic pathologies. Conventional MRI provides excellent anatomical characterization; however, overlapping imaging features may limit definitive diagnosis. Magnetic Resonance Spectroscopy (MRS) provides metabolic information which improves lesion characterization. Aim: To evaluate the role of Magnetic Resonance Spectroscopy in characterization of intracranial space occupying lesions. Materials and Methods: This observational cross-sectional study included 52 patients evaluated using 1.5 Tesla MRI with MRS. Conventional MRI sequences were followed by spectroscopy. Diagnostic accuracy of MRI alone and MRI combined with MRS was compared using histopathology and follow-up data. Results: MRI alone showed diagnostic accuracy of 86.5%, whereas combined MRI + MRS showed diagnostic accuracy of 96.2%. Conclusion: MRS significantly improves diagnostic confidence and helps reduce misclassification of lesions, potentially reducing the need for invasive procedures.