Clinical Profile and Predictors of In -Hospital Mortality in Stroke Patients a Prospective Observational Study

Background: In India, the prevalence of stroke is rising. This study set out to assess the clinical characteristics, risk factors, and predictors of in-hospital death among stroke patients. Material and Methods: We conducted a prospective observational study on stroke patients. We collected information on the stroke subtype, demographic profile, vascular risk factors, modified Rankin Scale (mRS), and factors linked to in-hospital mortality. Results: 256 stroke patients were enrolled (154 males and 102 female). The mean age of the patients was 60.9 ± 13.3 years (ranging: 26–86 years). 75% of cases were of ischemic stroke. The commonest risk factors were hypertension (61.7 %), tobacco smoking (34.7%), dyslipidaemia (26.9 %), diabetes (21.5 %). History of prior stroke was present in 16%, and seizures at onset in 6% of cases. At the time of admission 80.0% had mRS 4,5 and mean GCS on admission was 13.4±2.9. In-hospital mortality was 8.9 %, and was linked to the low GCS, high mRS score, UTI, sepsis, mechanical ventilation, bed sore, chest infection. On multivariate analysis factors related with mortality were duration of onset of symptoms to arrival to hospital (in hours) [AOR =.98; C.I 95%: (0.98-9.99), p < 0.03], hemorrhagic stroke [AOR = 2.7; C.I 95%: (1.0–7.4), p < 0.05] poor GCS [C.I 95%: (.67-–0.92), p < 0.003; AOR =.79]. Conclusion: In our study the mortality was related with haemorrhagic stroke, duration of onset of symptoms and intervention and low GCS. Early and rapid intervention can reduce the mortality. Keywords: Stroke; risk factors; In-Hospital Mortality.